Compound ID | 549

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PD 140248

Class: Fluoroquinolone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Broad spectrum antibiotic which a particular potency against Gram positives which also translated well in mouse models of both the parenteral or oral routes. When tested on Xanthomonas maltophilia (in vitro), its activity was similar to ciprofloxacin but worse that clinafloxacin and PD 131628.
Description: Sesnie J, Desaty T, Dever J, et al. In vivo efficacy of a novel fluroquinolone PD-140248. 33rd-Intersci-Conf-Antimicrobial-Agents-Chemother 1993; 306.
Institute where first reported: Pfizer, USA
Year first mentioned: 1993
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 432.4
Iso. SMILES: CC(C1CCN(C1)C2=C(C=C3C(=O)C(=CN(C3=N2)C4=C(C=C(C=C4)F)F)C(=O)O)F)N
InChI Key: VMHBXZLMBJVYFA-UHFFFAOYSA-N
Can. SMILES: CC(C1CCN(C1)C2=NC3=C(C=C2F)C(=O)C(=CN3C4=CC=C(C=C4F)F)C(=O)O)N
InChI: InChI=1S/C21H19F3N4O3/c1-10(25)11-4-5-27(8-11)20-16(24)7-13-18(29)14(21(30)31)9-28(19(13)26-20)17-3-2-12(22)6-15(17)23/h2-3,6-7,9-11H,4-5,8,25H2,1H3,(H,30,31)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5744444
Citations:
  • http://aac.asm.org/content/38/2/369.short
  • https://journals.asm.org/doi/10.1128/aac.37.12.2563?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed

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