Premafloxacin (U95376)

Class: Fluoroquinolone

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Was in development for veterinary medicine and is potent against both Gram positive and negative
Institute where first reported:	The Upjohn Company (Pfizer, USA)
Year first mentioned:	1995
Highest developmental phase:	Preclinical
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	C[C@@H]([C@@H]1CCN(C1)C2=C(C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(=O)O)OC)NC
Isomeric SMILES:	C[C@@H]([C@@H]1CCN(C1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F)NC
InChI:	InChI=1S/C21H26FN3O4/c1-11(23-2)12-6-7-24(9-12)18-16(22)8-14-17(20(18)29-3)25(13-4-5-13)10-15(19(14)26)21(27)28/h8,10-13,23H,4-7,9H2,1-3H3,(H,27,28)/t11-,12+/m0/s1
InChI Key:	SUQUWONDIBHQOZ-NWDGAFQWSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/71455

External links:
Guide to Pharmacology:	premafloxacin
Main Source:	https://www.sciencedirect.com/science/article/pii/S0022354915504449?via%3Dihub
Citation:	http://jac.oxfordjournals.org/content/38/4/742.full.pdf