Compound ID | 551

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PD 135661

Class: Fluoroquinolone

Spectrum of activity: Gram-positive
Details of activity: Active against a number of species of Mycobacteria including M. tuberculosis, M. fortuitum and M. smegmatis
Description: Renau TE, Gage JW, Dever JA, et al. Antituberculosis activity and side effect profiles of 8 new quinolones optimised for antimycobacterial effects. 36th-Intersci-Conf-Antimicrobial-Agents-Chemother 1996; 136.
Institute where first reported: Parke Davis Pharmaceutical Research (Pfizer, USA)
Year first mentioned: 1996
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 464.36
Iso. SMILES: CC1=CN(C(=O)NC1=O)C2C=CC(O2)COP3(=O)OCC4=C(O3)C=CC(=C4)CCC(=O)O
InChI Key: VEDIEJLAXGGJHK-UHFFFAOYSA-N
Can. SMILES: CC1=CN(C2C=CC(COP3(=O)OCC4=CC(=CC=C4O3)CCC(=O)O)O2)C(=O)NC1=O
InChI: InChI=1S/C20H21N2O9P/c1-12-9-22(20(26)21-19(12)25)17-6-4-15(30-17)11-29-32(27)28-10-14-8-13(3-7-18(23)24)2-5-16(14)31-32/h2,4-6,8-9,15,17H,3,7,10-11H2,1H3,(H,23,24)(H,21,25,26)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/44328594
Citation: https://academic.oup.com/jac/article/38/4/742/815396?login=true

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