Compound ID | 553

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PD-161148

Class: Fluoroquinolone

Spectrum of activity: Gram-positive
Details of activity: Active against a number of species of Mycobacteria including M. tuberculosis, M. fortuitum and M. smegmatis
Description: Renau TE, Gage JW, Dever JA, et al. Antituberculosis activity and side effect profiles of 8 new quinolones optimised for antimycobacterial effects. 36th-Intersci-Conf-Antimicrobial-Agents-Chemother 1996; 136.
Institute where first reported: Parke Davis Pharmaceutical Research (Pfizer, USA)
Year first mentioned: 1996
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 389.42
Iso. SMILES: CCC1CN(CCN1)C2=C(F)C=C3C(=C2OC)N(C=C(C(=O)O)C3=O)C4CC4
InChI Key: QNBJTZBMBAOFDX-UHFFFAOYSA-N
Can. SMILES: CCC1CN(CCN1)C2=C(C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(=O)O)OC
InChI: InChI=1S/C20H24FN3O4/c1-3-11-9-23(7-6-22-11)17-15(21)8-13-16(19(17)28-2)24(12-4-5-12)10-14(18(13)25)20(26)27/h8,10-12,22H,3-7,9H2,1-2H3,(H,26,27)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/substance/275147295
Citation: https://journals.asm.org/doi/10.1128/aac.40.10.2363

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