Compound ID | 554

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PD 161314

Class: Fluoroquinolone

Spectrum of activity: Gram-positive
Details of activity: Active against a number of species of Mycobacteria including M. tuberculosis, M. fortuitum and M. smegmatis
Description: Renau TE, Gage JW, Dever JA, et al. Antituberculosis activity and side effect profiles of 8 new quinolones optimised for antimycobacterial effects. 36th-Intersci-Conf-Antimicrobial-Agents-Chemother 1996; 136.
Institute where first reported: Parke Davis Pharmaceutical Research (Pfizer, USA)
Year first mentioned: 1996
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 361.41
Iso. SMILES: CC1CN(CCN1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C(C)(C)C)F
InChI Key: ZMTUMOZDZAJLFA-UHFFFAOYSA-N
Can. SMILES: CC1CN(CCN1)C2=CC3=C(C=C2F)C(=O)C(=CN3C(C)(C)C)C(=O)O
InChI: InChI=1S/C19H24FN3O3/c1-11-9-22(6-5-21-11)16-8-15-12(7-14(16)20)17(24)13(18(25)26)10-23(15)19(2,3)4/h7-8,10-11,21H,5-6,9H2,1-4H3,(H,25,26)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/459968
Citation: https://journals.asm.org/doi/10.1128/aac.40.10.2363

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