Compound ID | 556

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PD 163048

Class: Fluoroquinolone

Spectrum of activity: Gram-positive
Details of activity: Active against a number of species of Mycobacteria including M. tuberculosis, M. fortuitum and M. smegmatis
Description: Renau TE, Gage JW, Dever JA, et al. Antituberculosis activity and side effect profiles of 8 new quinolones optimised for antimycobacterial effects. 36th-Intersci-Conf-Antimicrobial-Agents-Chemother 1996; 136.
Institute where first reported: Parke Davis Pharmaceutical Research (Pfizer, USA)
Year first mentioned: 1996
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 362.4
Iso. SMILES: CC1CN(CCN1)C2=C(C=C3C(=O)C(=CN(C3=N2)C(C)(C)C)C(=O)O)F
InChI Key: QXNOSGDKQAIMRL-UHFFFAOYSA-N
Can. SMILES: CC1CN(CCN1)C2=NC3=C(C=C2F)C(=O)C(=CN3C(C)(C)C)C(=O)O
InChI: InChI=1S/C18H23FN4O3/c1-10-8-22(6-5-20-10)16-13(19)7-11-14(24)12(17(25)26)9-23(15(11)21-16)18(2,3)4/h7,9-10,20H,5-6,8H2,1-4H3,(H,25,26)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/459970
Citation: https://journals.asm.org/doi/10.1128/aac.40.10.2363

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