Compound ID | 563

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DK-507k

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule;
Spectrum of activity: Gram-positive
Mechanism of action: Unknown
Target Pathogen: Active against methicillin-resistant Staphylococcus aureus and pathogen causing community-acquired pneumoniae
Institute where first reported: Daiichi Pharmaceutical; Pfizer
Year first mentioned: 2001
Highest development stage: Phase 1
Development status: Inactive
Reason dropped: Pfizer and Daiichi announced discontinuation of this antibiotic in 2004 after analysis of Phase I trial data
Chemical structure(s):
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Molecular weight: 405.4
Iso. SMILES: COC1=C2C(=CC(=C1N3C[C@H](C4(C3)CC4)N)F)C(=O)C(=CN2[C@@H]5C[C@@H]5F)C(=O)O
InChI Key: JYRHGXXQSIPDDP-IACUBPJLSA-N
Can. SMILES: COC1=C(C(=CC2=C1N(C=C(C2=O)C(=O)O)[C@@H]3C[C@@H]3F)F)N4C[C@H](C5(CC5)C4)N
InChI: InChI=1S/C20H21F2N3O4/c1-29-18-15-9(17(26)10(19(27)28)6-25(15)13-5-11(13)21)4-12(22)16(18)24-7-14(23)20(8-24)2-3-20/h4,6,11,13-14H,2-3,5,7-8,23H2,1H3,(H,27,28)/t11-,13+,14+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5271826
Guide to Pharmacology: DK-507k
Citation: https://journals.asm.org/doi/10.1128/aac.47.12.3750-3759.2003

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