DK-507k

Class: Fluoroquinolone

Spectrum of activity:	Gram-negative
Details of activity:	Activity against MRSA and CAP
Institute where first reported:	Daiichi Pharmaceutical; Pfizer
Year first mentioned:	2001
Highest developmental phase:	Phase 1
Development status:	Inactive
Reason Dropped:	Pfizer and Daiichi announced discontinuation of this antibiotic in 2004 after analysis of Phase I trial data

Chemical structure(s):
Canonical SMILES:	COC1=C(C(=CC2=C1N(C=C(C2=O)C(=O)O)[C@@H]3C[C@@H]3F)F)N4C[C@H](C5(CC5)C4)N
Isomeric SMILES:	COC1=C2C(=CC(=C1N3C[C@H](C4(C3)CC4)N)F)C(=O)C(=CN2[C@@H]5C[C@@H]5F)C(=O)O
InChI:	InChI=1S/C20H21F2N3O4/c1-29-18-15-9(17(26)10(19(27)28)6-25(15)13-5-11(13)21)4-12(22)16(18)24-7-14(23)20(8-24)2-3-20/h4,6,11,13-14H,2-3,5,7-8,23H2,1H3,(H,27,28)/t11-,13+,14+/m0/s1
InChI Key:	JYRHGXXQSIPDDP-IACUBPJLSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5271826

External links:
Guide to Pharmacology:	DK-507k
Main Source:	https://journals.asm.org/doi/10.1128/aac.47.12.3750-3759.2003