Olamufloxacin (HSR-903)

Class: Fluoroquinolone

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Potent antibiotic activity against a number of tested clinical isolates including PRSP, M. catarrhalis and B. pertussis to name a few
Description:	Yoshizumi S, Domon H, Miyazaki S, et al. In vitro and in vivo activity of HSR-9903 against major respiratory pathogens. 38th-Intersci-Conf-Antimicrobial-Agents-Chemother 1998; 253
Institute where first reported:	Abbott Japan, Japan
Year first mentioned:	1998
Highest developmental phase:	Phase 3
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	CC1=C(C(=C(C2=C1N(C=C(C2=O)C(=O)O)C3CC3)N)F)N4C[C@H](C5(CC5)C4)N
Isomeric SMILES:	CC1=C2C(=C(C(=C1N3C[C@H](C4(C3)CC4)N)F)N)C(=O)C(=CN2C5CC5)C(=O)O
InChI:	InChI=1S/C20H23FN4O3/c1-9-16-13(18(26)11(19(27)28)6-25(16)10-2-3-10)15(23)14(21)17(9)24-7-12(22)20(8-24)4-5-20/h6,10,12H,2-5,7-8,22-23H2,1H3,(H,27,28)/t12-/m1/s1
InChI Key:	LEILBPMISZFZQK-GFCCVEGCSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/477670

External links:
Guide to Pharmacology:	olamufloxacin
Main Source:	https://journals.asm.org/doi/10.1128/aac.41.6.1326