Compound ID | 565

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Olamufloxacin (HSR-903)

Class: Fluoroquinolone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Potent antibiotic activity against a number of tested clinical isolates including PRSP, M. catarrhalis and B. pertussis to name a few
Description: Yoshizumi S, Domon H, Miyazaki S, et al. In vitro and in vivo activity of HSR-9903 against major respiratory pathogens. 38th-Intersci-Conf-Antimicrobial-Agents-Chemother 1998; 253
Institute where first reported: Abbott Japan, Japan
Year first mentioned: 1998
Highest developmental phase: Phase 3
Development status: Inactive
Chemical structure(s):
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Molecular weight: 386.42
Iso. SMILES: CC1=C2C(=C(C(=C1N3C[C@H](C4(C3)CC4)N)F)N)C(=O)C(=CN2C5CC5)C(=O)O
InChI Key: LEILBPMISZFZQK-GFCCVEGCSA-N
Can. SMILES: CC1=C(C(=C(C2=C1N(C=C(C2=O)C(=O)O)C3CC3)N)F)N4C[C@H](C5(CC5)C4)N
InChI: InChI=1S/C20H23FN4O3/c1-9-16-13(18(26)11(19(27)28)6-25(16)10-2-3-10)15(23)14(21)17(9)24-7-12(22)20(8-24)4-5-20/h6,10,12H,2-5,7-8,22-23H2,1H3,(H,27,28)/t12-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/477670
Guide to Pharmacology: olamufloxacin
Citation: https://journals.asm.org/doi/10.1128/aac.41.6.1326

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