Compound ID | 583
Walkmycin E
Class: Small molecule antibacterial agent
| Agent Type: | Small molecule; Direct acting; Antivirulence; |
| Spectrum of activity: | Gram-positive |
| Mechanism of action: | Histidine kinase inhibitor; inhibits the two component system WalK/ WalR, which is essential for cell wall metabolism |
| Target Pathogen: | Active against Staphylococcus aureus |
| Description: | Igarashi M, Eguchi Y, Umekita M, et al. Walkmycins, the Novel Histidine Kinase Inhibitors. 50th-ICAAC 2010 |
| Institute where first reported: | Inst. of Microbial Chemistry, Japan, Kinki Univ. Sch. of Agriculture, Japan. |
| Year first mentioned: | 2010 |
| Development status: | Experimental |
| External links: |
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