Compound ID | 591

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RWJ-60563

Class: Antivirulence agent (two-component system inhibitor)

Spectrum of activity: Gram-positive
Details of activity: Potent activity against multidrug resistant S. aureus and E. faecium
Description: Melton JL, Fernandez JA, Frechette RF, et al. In vivo activity of a novel series of antibacterial agents that inhibit the bacterial two component signal transduction system. 37th-Intersci-Conf-Antimicrobial-Agents-Chemother 1997; 185.
Institute where first reported: Johnson & Johnson Pharmaceutical R&D, USA
Year first mentioned: 1997
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Provided no protection to mice
Chemical structure(s):
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Molecular weight: 449.59
Iso. SMILES: C1=CC=C(C=C1)C(CCOC2=CC=C(C=C2)CCN=C(N)N)(C3=CC=CC=C3)C4=CC=CC=C4
InChI Key: AJKCPFPHDCULCG-UHFFFAOYSA-N
Can. SMILES: C1=CC=C(C=C1)C(CCOC2=CC=C(C=C2)CCN=C(N)N)(C3=CC=CC=C3)C4=CC=CC=C4
InChI: InChI=1S/C30H31N3O/c31-29(32)33-22-20-24-16-18-28(19-17-24)34-23-21-30(25-10-4-1-5-11-25,26-12-6-2-7-13-26)27-14-8-3-9-15-27/h1-19H,20-23H2,(H4,31,32,33)
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Citation:

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