Compound ID | 591

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RWJ-60563

Class: Antivirulence agent

Agent Type: Synthetic; Small molecule; Direct acting; Antivirulence;
Spectrum of activity: Gram-positive
Mechanism of action: Antivirulence agent; two-component system inhibitor
Target Pathogen: Active against multidrug-resistant Staphylococcus aureus and Enterococcus faecium
Description: Derivative of RWJ-49815; Melton JL, Fernandez JA, Frechette RF, et al. In vivo activity of a novel series of antibacterial agents that inhibit the bacterial two component signal transduction system. 37th-Intersci-Conf-Antimicrobial-Agents-Chemother 1997; 185.
Institute where first reported: Johnson & Johnson Pharmaceutical R&D, USA
Year first mentioned: 1997
Development status: Experimental
Reason dropped: Provided no protection to mice
Chemical structure(s):
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Molecular weight:
Iso. SMILES: NC(NCCC=1C=CC(=CC1)OCCC(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=S
InChI Key: ZRQOHCQLOJUGMT-UHFFFAOYSA-N
Can. SMILES: C1=CC=C(C=C1)C(CCOC2=CC=C(C=C2)CCNC(=S)N)(C3=CC=CC=C3)C4=CC=CC=C4
InChI: InChI=1S/C30H30N2OS/c31-29(34)32-22-20-24-16-18-28(19-17-24)33-23-21-30(25-10-4-1-5-11-25,26-12-6-2-7-13-26)27-14-8-3-9-15-27/h1-19H,20-23H2,(H3,31,32,34)
External links:
Citation: https://doi.org/10.1073/pnas.95.9.5317

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