Compound ID | 595
CHIR 380
Class: Macrolide (16-membered macrolide, ketolide)
| Spectrum of activity: | Gram-positive |
| Details of activity: | Activity against S. pneumoniae and S. pyrogenes is similar to that of telithromycin, however, is effective against macrolide sensitive and resistant bacteria. Additionally in comparison to telithromycin demonstrates a greater lung to plasma, with greater distribution and half life making a good candidate for treatment of respiratory infections (1). |
| Description: | Chu D, Barker L, Shawar R, et al. CHIR 380 and CHIR 988: Two novel potent ketolides. 43rd-ICAAC-2003 2003;245. |
| Institute where first reported: | Chiron Corp. (Novartis, Switzerland) |
| Year first mentioned: | 2003 |
| Highest developmental phase: | Preclinical |
| Development status: | Inactive |
| External links: | |
| Citation: |
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