Compound ID | 614

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GW 708408

Class: Macrolide

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Anti-pseudomonal activity both erythromycin A susceptible and resistant strains and against Haemophilus influenzaae similar to that of telithromycin
Institute where first reported: Penn State Hershey Medical Centre, USA
Year first mentioned: 2004
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 797.98
Iso. SMILES: O=C1O[C@@]2([C@@H](CC)OC(=O)[C@@H](C(C([C@H]([C@](C[C@H](C(C([C@@]2([H])[C@@H]1NCCN3C=NC(C4=CN=CC=C4)=C3)C)=O)C)(C)OC)O[C@H]5[C@H](O)[C@@H](N(C)C)C[C@@H](C)O5)C)=O)C)C
InChI Key: YJULEOHGCUTYMC-UTNACSKBSA-N
Can. SMILES: CC[C@@H]1[C@]2(C)[C@@]([H])(C(C)C(=O)[C@H](C)C[C@](C)([C@@H](C(C)C(=O)[C@@H](C)C(=O)O1)O[C@H]3[C@@H]([C@H](C[C@@H](C)O3)N(C)C)O)OC)[C@@H](C(=O)O2)NCCN4C=C(C5=CN=CC=C5)N=C4
InChI: InChI=1S/C42H63N5O10/c1-12-31-42(8)32(33(39(52)57-42)44-16-17-47-21-29(45-22-47)28-14-13-15-43-20-28)25(4)34(48)23(2)19-41(7,53-11)37(26(5)35(49)27(6)38(51)55-31)56-40-36(50)30(46(9)10)18-24(3)54-40/h13-15,20-27,30-33,36-37,40,44,50H,12,16-19H2,1-11H3/t23-,24-,25?,26?,27-,30+,31-,32+,33+,36-,37-,40+,41-,42-/m1/s1
External links:
Citation: https://journals.asm.org/doi/10.1128/aac.48.11.4113-4119.2004#F1

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