Compound ID | 620
EP-014887
Class: Macrolide (oxime 3,6-bicyclolide)
| Spectrum of activity: | Gram-positive |
| Details of activity: | Binds to the peptidyl transferase component of the 50S subunit of ribosomes, thus inhibiting peptide bond formation and bacterial protein synthesis. It is active against Gram-positive bacteria. |
| Description: | Tang D, Polemeropoulos A, Jiang L, et al. Discovery of EP-014887: a novel oxime 3,6-bicyclolide with high potency against MRSA and a favorable in vivo efficacy profile. 47th-ICAAC-2007 2007;246-247 |
| Institute where first reported: | Enanta Pharmaceuticals, USA |
| Year first mentioned: | 2007 |
| Development status: | Discontinued |
| External links: | |
| Structure link: | https://www.sciencedirect.com/science/article/abs/pii/S0960894X08009049?via%3Dihub |
| Citations: |
|
AntibioticDB is supported by GARDP.
If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions
The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.