Compound ID | 623
CP-929898
Class: Protein synthesis inhibitor
| Spectrum of activity: | Gram-positive |
| Mechanism of action: | Protein synthesis inhibitor. Inhibits bacterial ribosomal peptidyl transferase |
| Target Pathogen: | Active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, and penicillin-resistant Streptococcus pneumoniae |
| Description: | Semisynthetic compound derived from hygromycin A; Huband MD, Brighty KE, Monohan R, et al. In vitro antibacterial activity of CE-156811, CP-919474, and CP-929898: novel hygromycin A analogs compared to levofloxacin and other antibacterial agents against 1220 recent clinical isolates. 46th-Intersci-Conf-Antimicrobial-Agents-Chemother 2006;230 |
| Institute where first reported: | Pfizer, USA |
| Year first mentioned: | 2006 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://doi.org/10.1016/j.bmcl.2010.11.022 |
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