Compound ID | 626

Update compound information

PTX2416

Class: Beta-lactam (monobactam)

Spectrum of activity: Gram-positive
Details of activity: Potent against Gram negatives, was intended to go into clinical trials for Pseudomonas infections.
Institute where first reported: PanTherix Ltd, UK (Licensed); Naeja Pharmaceutical Inc, Canada (Ceased R&D)
Year first mentioned: 2003
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: PanTherix couldn't raise $15 million to take this further (1)
Chemical structure(s):
Click here for structure editor
Molecular weight: 526.55
Iso. SMILES: C[C@H]1[C@@H](C(=O)N1S(=O)(=O)[O-])NC(=O)/C(=N\OCC2=CC(=O)C(=CN2O)O)/C3=CSC(=N3)N.[K+]
InChI Key: POCDCKLAQOXNPX-QVBHGQIKSA-M
Can. SMILES: C[C@H]1[C@@H](C(=O)N1S(=O)(=O)[O-])NC(=O)/C(=N\OCC2=CC(=O)C(=CN2O)O)/C3=CSC(=N3)N.[K+]
InChI: InChI=1S/C15H16N6O9S2.K/c1-6-11(14(25)21(6)32(27,28)29)18-13(24)12(8-5-31-15(16)17-8)19-30-4-7-2-9(22)10(23)3-20(7)26;/h2-3,5-6,11,23,26H,4H2,1H3,(H2,16,17)(H,18,24)(H,27,28,29);/q;+1/p-1/b19-12-;/t6-,11-;/m0./s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/129846797
Citations:
  • http://adisinsight.springer.com/drugs/800016448

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