Compound ID | 634

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DQ-1

Class: MurF inhibitor (diarylquinoline)

Spectrum of activity: Gram-positive
Details of activity: Cell wall inhibitor leading to lysis; demonstrated activity against wt E.coli, however this was after permeation of polymixin B nanopeptide
Institute where first reported: Johnson & Johnson Pharmaceutical Research & Development, US
Year first mentioned: 2007
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Low activity against Gram negatives such as E. coli due to issues of entering cell, but this was an early member of its class, optimisation has led to bedaquiline being approved by FDA in 2012.
Chemical structure(s):
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Molecular weight: 456.58
Iso. SMILES: CN(C)CC[C@@](C1=CC=CC=C1)(O)[C@H](C2=CC=CC=C2)C3=CC4=C(N=C3OC)C=CC(OC)=C4
InChI Key: NDCIQFVAMXGSDQ-PXJZQJOASA-N
Can. SMILES: CN(C)CC[C@](C1=CC=CC=C1)([C@H](C2=CC=CC=C2)C3=C(N=C4C=CC(=CC4=C3)OC)OC)O
InChI: InChI=1S/C29H32N2O3/c1-31(2)18-17-29(32,23-13-9-6-10-14-23)27(21-11-7-5-8-12-21)25-20-22-19-24(33-3)15-16-26(22)30-28(25)34-4/h5-16,19-20,27,32H,17-18H2,1-4H3/t27-,29+/m1/s1
External links:
Citation: https://journals.asm.org/doi/full/10.1128/AAC.00166-09

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