Compound ID | 635

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DQ-2

Class: MurF inhibitor (diarylquinoline)

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Cell wall inhibitor leading to lysis; demonstrated activity in E. coli alike DQ-1 but also demonstrated activity agasinst Gram positives such as MRSA
Institute where first reported: Johnson & Johnson Pharmaceutical Research & Development, USA
Highest developmental phase: Phase 1
Development status: Inactive
Reason Dropped: Low activity against Gram negatives such as E. coli due to issues of entering cell, but this was an early member of its class, optimisation has led to bedaquiline being approved by FDA in 2012.
Chemical structure(s):
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Molecular weight: 484.63
Iso. SMILES: CN(C)CC[C@](CCC1=CC=CC=C1)(O)[C@H](C2=CC=CC=C2)C3=CC4=C(N=C3OC)C=CC(OC)=C4
InChI Key: QUCYLWMCJCNQQW-VEEOACQBSA-N
Can. SMILES: CN(C)CC[C@@](CCC1=CC=CC=C1)([C@H](C2=CC=CC=C2)C3=C(N=C4C=CC(=CC4=C3)OC)OC)O
InChI: InChI=1S/C31H36N2O3/c1-33(2)20-19-31(34,18-17-23-11-7-5-8-12-23)29(24-13-9-6-10-14-24)27-22-25-21-26(35-3)15-16-28(25)32-30(27)36-4/h5-16,21-22,29,34H,17-20H2,1-4H3/t29-,31+/m1/s1
External links:
Citation: https://journals.asm.org/doi/full/10.1128/AAC.00166-09

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