Compound ID | 64

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AP138

Synonym(s): AP-138  |  AP 138  |  Plectasin

Class: Antimicrobial peptide

Agent Type: Semisynthetic; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Cell wall synthesis inhibitor. Binds to lipid II
Target Pathogen: Active against methicillin resistant Staphylococcus aureus implant infections
Propensity to select resistant mutants: Yes
Description: Semisynthetic compound from natural product produced by Pichia pastoris
Institute where first reported: Adenium Biotech, Denmark
Year first mentioned: 2004
Development status: Experimental
External links:
Citations:
  • https://www.escmid.org/escmid_publications/escmid_elibrary/?q=AP138+&id=2173&L=0&x=0&y=0
  • https://www.nature.com/nature/journal/v437/n7061/full/nature04051.html
  • https://www.nature.com/articles/s41564-024-01696-9
  • https://pubmed.ncbi.nlm.nih.gov/30532539/

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