Compound ID | 641

Update compound information

PA-1297

Synonym(s): PA-1,297  |  PA 1297

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule;
Spectrum of activity: Gram-negative & Antimycobacterial
Mechanism of action: Unknown
Target Pathogen: Active against Mycobacterium tuberculosis and Helicobacter pylori
Description: A nitroimidazopyran derivative; Ritchie HD, Orta GJ, Harris LM, et al. Toxicology and toxicokinetics of PA-824 and PA 1297, two nitroimidazopyran antitubercular agents in mice. 37th-Intersci-Conf-Antimicrobial-Agents-Chemother 1997; 150.
Institute where first reported: Pathogenesis Corp. (Chiron Corp., USA)
Year first mentioned: 1997
Development status: Experimental
Chemical structure(s):
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Molecular weight: 388.26
Iso. SMILES: C1[C@@H](COC2=NC(=CN21)[N+](=O)[O-])OC(=O)NC3=CC=C(C=C3)OC(F)(F)F
InChI Key: BFGKIVVTPDSBJF-JTQLQIEISA-N
Can. SMILES: C1=C(C=CC(=C1)OC(F)(F)F)NC(=O)O[C@H]2CN3C=C(N=C3OC2)[N+](=O)[O-]
InChI: InChI=1S/C14H11F3N4O6/c15-14(16,17)27-9-3-1-8(2-4-9)18-13(22)26-10-5-20-6-11(21(23)24)19-12(20)25-7-10/h1-4,6,10H,5,7H2,(H,18,22)/t10-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/476514
Citation: https://www.jstor.org/stable/4481636

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