Compound ID | 643
Pretomanid
Synonym(s): PA-824
Class: Nitroimidazole
| Spectrum of activity: | Gram-positive |
| Details of activity: | Active against Mycobacterium tuberculosis |
| Description: | 1. Bake WR, Keeler EL, Cai S, et al. Identification of PA-834, a novel 6-nitroimidazopyran antitubercular agent, using high throughput synthesis and screening methodology. 36th-Intersci-Conf-Antimicrobial-Agents-Chemother 1996; 137. 2. Ritchie HD, Orta GJ, Harris LM, et al. Toxicology and toxicokinetics of PA-824 and PA 1297, two nitroimidazopyran antitubercular agents in mice. 37th-Intersci-Conf-Antimicrobial-Agents-Chemother 1997; 150. |
| Institute where first reported: | Pathogenesis Corp. (Chiron Corp., USA) |
| Year first mentioned: | 1997 |
| Highest developmental phase: | Phase 3 |
| Development status: | Active |
| Reason Dropped: | Poor oral bioavailability which alothough can be improved through use of lipid coated cyclodextrin formulations would increase cost a lot. |
| External links: | |
| PubChem link: | https://pubchem.ncbi.nlm.nih.gov/compound/456199 |
| Citations: |
|
AntibioticDB is supported by GARDP.
If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions
The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.