Compound ID | 644

Update compound information

Rodaplutin

Synonym(s): Sch 36605

Class: Nucleoside

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Posseses anti-inflamatory activity. Related to blasticidin S. They inhibit peptide chain elongation
Institute where first reported: Schering Corp. (Merck & Co., USA)
Year first mentioned: 1986
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Quite Toxic to mice (IV LD50: 3.75mg/kg)
Chemical structure(s):
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Molecular weight: 565.62
Iso. SMILES: CC(C)CC(C(=O)NC(CCN(C)C(=N)N)CC(=O)NC1C=CC(OC1C(=O)O)N2C=C(C(=NC2=O)N)CO)N
InChI Key: MGPVTRZZQCEQDF-UHFFFAOYSA-N
Can. SMILES: CC(C)CC(C(=O)NC(CCN(C)C(=N)N)CC(=O)NC1C=CC(N2C=C(CO)C(=NC2=O)N)OC1C(=O)O)N
InChI: InChI=1S/C24H39N9O7/c1-12(2)8-15(25)21(36)29-14(6-7-32(3)23(27)28)9-17(35)30-16-4-5-18(40-19(16)22(37)38)33-10-13(11-34)20(26)31-24(33)39/h4-5,10,12,14-16,18-19,34H,6-9,11,25H2,1-3H3,(H3,27,28)(H,29,36)(H,30,35)(H,37,38)(H2,26,31,39)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/163787
Citations:
  • https://www.ncbi.nlm.nih.gov/pubmed/3346189

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