Compound ID | 645

Update compound information

AM-7359

Synonym(s): AM7359  |  AM 7359

Class: Oxazolidinone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against methicillin and linezolid-resistant and -susceptible Staphylococcus aureus and vancomycin and linezolid-resistant and -susceptible Enterococcus faecalis
Description: Ebisu H, Abuki R, Takei M, et al. Novel oxazolidinones: antibacterial activities against respiratory pathogens and drug-resistant gram-positive bacteria. 46th-Intersci-Conf-Antimicrobial-Agents-Chemother 2006;212
Institute where first reported: Kyorin Pharmaceutical, Japan; Merck & Co, USA
Year first mentioned: 2006
Highest development stage: Preclinical
Development status: Experimental
Reason dropped: No development has been reported and has been in pre-clinical trials since 2006 indicating discontinuation
Chemical structure(s):
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Molecular weight: 481.91
Iso. SMILES: C1[C@@H]2[C@@H](C2(C#N)C3=NC=C(C=C3)C4=C(C=C(C=C4)N5C[C@@H](OC5=O)CN6C=CN=N6)F)CN1.Cl
InChI Key: LMTBFEVMESUQCJ-DRGVWGSESA-N
Can. SMILES: C1=C(C=NC(=C1)C2(C#N)[C@H]3CNC[C@H]32)C4=C(C=C(C=C4)N5C[C@H](CN6C=CN=N6)OC5=O)F.Cl
InChI: InChI=1S/C23H20FN7O2.ClH/c24-20-7-15(31-12-16(33-22(31)32)11-30-6-5-28-29-30)2-3-17(20)14-1-4-21(27-8-14)23(13-25)18-9-26-10-19(18)23;/h1-8,16,18-19,26H,9-12H2;1H/t16-,18-,19+,23?;/m0./s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9549078
Citation: https://doi.org/10.1179/joc.2007.19.3.249

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