Compound ID | 650

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Sutezolid

Synonym(s): PNU-100480  |  PF-02341272  |  U-100480

Class: Oxazolidinone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Antimycobacterial
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Mycobacterium isolates
Description: Huband MD, et al. In Vitro Activity of PNU-100480, PNU-101603, and PNU-101244: Novel Oxazolidinone Antibacterials versus Mycobacterium tuberculosis. 49th-ICAAC 2009
Institute where first reported: Pfizer, USA
Year first mentioned: 1999
Highest development stage: Phase 2 (NCT05971602)
Development status: Active
Reason dropped: Not as active as the lead compound PNU-100481
Chemical structure(s):
Click here for structure editor
Molecular weight:
Iso. SMILES: CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCSCC3)F
InChI Key: FNDDDNOJWPQCBZ-ZDUSSCGKSA-N
Can. SMILES: CC(=O)NC[C@H]1CN(C2=CC=C(C(=C2)F)N3CCSCC3)C(=O)O1
InChI: InChI=1S/C16H20FN3O3S/c1-11(21)18-9-13-10-20(16(22)23-13)12-2-3-15(14(17)8-12)19-4-6-24-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/465951
Guide to Pharmacology: sutezolid
Citations:
  • https://doi.org/10.1016/j.bmcl.2004.01.010
  • https://doi.org/10.1371/journal.pone.0030479
  • https://doi.org/10.1128/aac.43.5.1189

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