Compound ID | 651

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PNU-101603

Class: Oxazolidinone

Spectrum of activity: Gram-negative
Details of activity: Was tested against Mycobacterium tuberculosis and S. aureus along with another promising compound PNU-100480. This compound was not as active against linezolid or PNU-100480 against either Mycobacterium tuberculosis or S. aureus
Description: Huband MD, et al. In Vitro Activity of PNU-100480, PNU-101603, and PNU-101244: Novel Oxazolidinone Antibacterials versus Mycobacterium tuberculosis. 49th-ICAAC 2009
Institute where first reported: Pfizer, USA
Year first mentioned: 2009
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Not as active as the lead compound PNU-100480
Chemical structure(s):
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Molecular weight: 369.41
Iso. SMILES: CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCS(=O)CC3)F
InChI Key: WNRIDZUNMXATND-ZDUSSCGKSA-N
Can. SMILES: CC(=O)NC[C@H]1CN(C2=CC=C(C(=C2)F)N3CCS(=O)CC3)C(=O)O1
InChI: InChI=1S/C16H20FN3O4S/c1-11(21)18-9-13-10-20(16(22)24-13)12-2-3-15(14(17)8-12)19-4-6-25(23)7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/465952
Citation:

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