Compound ID | 653

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PNU-140457

Class: Oxazolidinone

Spectrum of activity: Gram-positive
Details of activity: Linezolid derivative (triazole) that gave MIC values of 1mg/ml and 0.5mg/ml for S. aureus and S. pneumoniae, respectively.
Description: Hutchinson DK, Barbachyn MR, Hester JB, et al. Synthesis and antibacterial activity of azolphenyloxazolidinones having nitrogen-bound five-membered heterocyclic rings. 38th-Intersci-Conf-Antimicrobial-Agents-Chemother 1998; 267.
Institute where first reported: Pharmacia Corp., USA
Year first mentioned: 1998
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 319.29
Iso. SMILES: CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)N3C=CN=N3)F
InChI Key: JJBMTUJJQREOPY-NSHDSACASA-N
Can. SMILES: CC(=O)NC[C@H]1CN(C2=CC=C(C(=C2)F)N3C=CN=N3)C(=O)O1
InChI: InChI=1S/C14H14FN5O3/c1-9(21)16-7-11-8-19(14(22)23-11)10-2-3-13(12(15)6-10)20-5-4-17-18-20/h2-6,11H,7-8H2,1H3,(H,16,21)/t11-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/10567624
Citation:

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