Compound ID | 669

Update compound information

BB-3497

Synonym(s): BB3497  |  BB 3497

Class: Protein synthesis inhibitor

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Protein synthesis inhibitor. Peptide deformylase inhibitor
Target Pathogen: Active against Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae
Description: An N-formyl-hydroxylamine derivative
Institute where first reported: British Biotech
Year first mentioned: 2000
Development status: Experimental
Reason dropped: Succeeded by the metalloenzyme inhibitors programme by Vernalis; high frequency selection of resistant mutants
Chemical structure(s):
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Molecular weight: 329.44
Iso. SMILES: CCCC[C@H](CN(C=O)O)C(=O)N[C@H](C(=O)N(C)C)C(C)(C)C
InChI Key: AVDLWYHBABSSHC-CHWSQXEVSA-N
Can. SMILES: CCCC[C@H](CN(C=O)O)C(=O)N[C@H](C(=O)N(C)C)C(C)(C)C
InChI: InChI=1S/C16H31N3O4/c1-7-8-9-12(10-19(23)11-20)14(21)17-13(16(2,3)4)15(22)18(5)6/h11-13,23H,7-10H2,1-6H3,(H,17,21)/t12-,13-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/159596
Citation: https://doi.org/10.1128/aac.45.2.563-570.2001

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