Compound ID | 673

Update compound information

VIC-104959

Synonym(s): LBM-415  |  NVP-PDF-713

Class: Peptide deformylase inhibitor

Spectrum of activity: Gram-negative
Details of activity: Growth inhibitor; active against CAP
Institute where first reported: Vernalis, UK; Novartis, Switzerland; Pfizer, US
Year first mentioned: 2000
Highest developmental phase: Phase 1
Development status: Inactive
Reason Dropped: Toxicity issues (JS) and possible resistance issues
Chemical structure(s):
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Molecular weight: 396.41
Iso. SMILES: CCCC[C@H](CN(C=O)O)C(=O)N1CCC[C@H]1C(=O)N=C2C=CC(=CN2O)F
InChI Key: AYCMYBACERJYNY-HIFRSBDPSA-N
Can. SMILES: CCCC[C@H](CN(C=O)O)C(=O)N1CCC[C@H]1C(=O)N=C2C=CC(=CN2O)F
InChI: InChI=1S/C18H25FN4O5/c1-2-3-5-13(10-21(27)12-24)18(26)22-9-4-6-15(22)17(25)20-16-8-7-14(19)11-23(16)28/h7-8,11-13,15,27-28H,2-6,9-10H2,1H3/t13-,15+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9690139
Guide to Pharmacology: LBM-415
Citations:
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152502/
  • http://www.ncbi.nlm.nih.gov/pubmed/16189089

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