Compound ID | 674

Update compound information

VRC3852

Synonym(s): VRC-3852  |  VRC 3852

Class: Protein synthesis inhibitor

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Protein synthesis inhibitor. Peptide deformylase inhibitor
Target Pathogen: Active against Moraxella catarrhalis
Institute where first reported: Vernalis, UK; Novartis, Switzerland; Pfizer, US
Year first mentioned: 2000
Highest development stage: Preclinical
Development status: Experimental
Chemical structure(s):
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Molecular weight: 416.5
Iso. SMILES: O=C(CN(C(N1[C@@H](C(NC2=CC=CC=C2)=O)CCC1)=O)CCC3=CC=CS3)NO
InChI Key: ZCBXDURJENKZBJ-QGZVFWFLSA-N
Can. SMILES: C1=CC=C(C=C1)NC(=O)[C@H]2CCCN2C(=O)N(CCC3=CC=CS3)CC(=O)NO
InChI: InChI=1S/C20H24N4O4S/c25-18(22-28)14-23(12-10-16-8-5-13-29-16)20(27)24-11-4-9-17(24)19(26)21-15-6-2-1-3-7-15/h1-3,5-8,13,17,28H,4,9-12,14H2,(H,21,26)(H,22,25)/t17-/m1/s1
External links:
Citation: https://doi.org/10.1128/aac.46.9.2752-2764.2002

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