Compound ID | 676

Update compound information

VRC3375

Class: Peptide deformylase inhibitor

Spectrum of activity: Gram-negative
Details of activity: Growth inhibitor; active against CAP
Institute where first reported: Vernalis, UK; Novartis, Switzerland; Pfizer, US
Year first mentioned: 2000
Highest developmental phase: Phase 1
Development status: Inactive
Reason Dropped: Toxicity issues (JS) and possibly resistance issues as VRC3375 had a resistance build up frequency of 10E-6.5
Chemical structure(s):
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Molecular weight: 342.43
Iso. SMILES: CCCC[C@H](CC(=O)NO)C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C
InChI Key: XNOOIEVKOZAJEO-OLZOCXBDSA-N
Can. SMILES: CCCC[C@H](CC(=O)NO)C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C
InChI: InChI=1S/C17H30N2O5/c1-5-6-8-12(11-14(20)18-23)15(21)19-10-7-9-13(19)16(22)24-17(2,3)4/h12-13,23H,5-11H2,1-4H3,(H,18,20)/t12-,13+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/488029
Citations:
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152502/
  • http://www.ncbi.nlm.nih.gov/pubmed/16189089
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374925/

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