Compound ID | 677

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VRC4307

Class: Peptide deformylase inhibitor

Spectrum of activity: Gram-negative
Details of activity: Growth inhibitor; active against CAP
Institute where first reported: Vernalis, UK; Novartis, Switzerland; Pfizer, US
Year first mentioned: 2000
Highest developmental phase: Phase 1
Development status: Inactive
Reason Dropped: Toxicity issues (JS) and possible resistance issues
Chemical structure(s):
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Molecular weight: 409.5
Iso. SMILES: O=C(CN(C(N1[C@@H](C(NC2=NC=CS2)=O)CCC1)=O)CCC3CCCC3)NO
InChI Key: NCMNMULRWYVLMX-CQSZACIVSA-N
Can. SMILES: C1CCC(C1)CCN(CC(=O)NO)C(=O)N2CCC[C@@H]2C(=O)NC3=NC=CS3
InChI: InChI=1S/C18H27N5O4S/c24-15(21-27)12-22(10-7-13-4-1-2-5-13)18(26)23-9-3-6-14(23)16(25)20-17-19-8-11-28-17/h8,11,13-14,27H,1-7,9-10,12H2,(H,21,24)(H,19,20,25)/t14-/m1/s1
External links:
Citations:
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152502/
  • http://www.ncbi.nlm.nih.gov/pubmed/16189089
  • https://journals.asm.org/doi/10.1128/aac.46.9.2752-2764.2002

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