Compound ID | 681

Update compound information

CP-65-207

Class: Beta-lactam (penem)

Spectrum of activity: Gram-positive  &  Gram-negative
Description: Racemic 1:1 mixture of the R isomer (CP-65,207-R) and the S isomer (CP-65,207-S, CP-70,429, sulopenem) Foulds G, Knirsch AK, Lazar JD, et al. Pharmacokinetics of the penem CP-65,207 and its separate stereoisomers in humans. Antimicrobial Agents and Chemotherapy. 1991;35(4):665.
Institute where first reported: Pfizer, US
Year first mentioned: 1988
Highest developmental phase: Phase 1
Development status: Inactive
Reason Dropped: There is a sulphurous odour in the urine when there is a mix of isomers.
Chemical structure(s):
Click here for structure editor
Molecular weight: 371.43
Iso. SMILES: C[C@H]([C@@H]1[C@@H]2N(C1=O)C(=C(S2)SC3CCS(=O)C3)C(=O)[O-])O.[Na+]
InChI Key: MRHMJKHFABHUKB-VASRXWSJSA-M
Can. SMILES: C[C@H]([C@H]1C(=O)N2C(=C(SC3CCS(=O)C3)S[C@H]12)C(=O)[O-])O.[Na+]
InChI: InChI=1S/C12H15NO5S3.Na/c1-5(14)7-9(15)13-8(11(16)17)12(20-10(7)13)19-6-2-3-21(18)4-6;/h5-7,10,14H,2-4H2,1H3,(H,16,17);/q;+1/p-1/t5-,6?,7+,10-,21?;/m1./s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/23669324
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC245076/

  • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.