Compound ID | 688
BPI 23
Class: Antimicrobial peptide
| Spectrum of activity: | Gram-negative |
| Details of activity: | The immune system is throught to over react to LPS (liposacharides) of the invading bacteria resulting in the overexpression of cytokines and vasoactive nitric oxide which damages tissues. This is thought to result in sepsis. BPI-23 competes with LBP (liposaccharide binding protein) preventing binding to LPS receptors and hence protecting the host. |
| Description: | Marsh, Joan, and Jamie Goode. Antimicrobial peptides. Chichester, England New York: Wiley, 1994. Print. |
| Institute where first reported: | New York University, USA; XOMA Corp. USA |
| Year first mentioned: | 1992 |
| Highest developmental phase: | Phase 2 |
| Development status: | Inactive |
| External links: | |
| Citation: |
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