Compound ID | 692
Dermaseptin Derivative- K4-S4(1-13)
Class: Antimicrobial peptide
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | Demonstrated anti-pseudomonal activity |
| Propensity to select resistant mutants: | Yes |
| Description: | Navon-Venezia S, Feder R, Gaidukov L, etc., Antibacterial Properties of Dermaseptin S4 Derivatives with In Vivo Activity. Antimicrobial Agents and Chemotherapy. 2002;46(3):689. |
| Institute where first reported: | Tel-aviv Centre, Isreal |
| Year first mentioned: | 2001 |
| Development status: | Inactive |
| Reason Dropped: | Whilst toxicity is reduced in vivo, more optimisation is needed to reach toxicity profile of some clinically used antibiotics (1). |
AntibioticDB is supported by GARDP.
If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions
The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.