Compound ID | 693
K4-S4(1-16)
Synonym(s): Dermaseptin derivative K4-S4(1-16)
Class: Antimicrobial peptide
| Agent Type: | Semisynthetic; Direct acting; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | Membrane-active agent |
| Target Pathogen: | Active against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa |
| Propensity to select resistant mutants: | Yes |
| Description: | Dermaseptin S4 derivative with improved selectivity against prokaryotes (i.e. low haemolytic activity); Navon-Venezia S, Feder R, Gaidukov L, etc., Antibacterial Properties of Dermaseptin S4 Derivatives with In Vivo Activity. Antimicrobial Agents and Chemotherapy. 2002;46(3):689. |
| Institute where first reported: | Tel-aviv Centre, Isreal |
| Year first mentioned: | 2001 |
| Development status: | Experimental |
| Reason dropped: | Toxicity profile inferior to clinically used antibiotics |
| External links: | |
| Citations: |
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