Compound ID | 696

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GE37468A

Class: Antimicrobial peptide (thiazolyl peptide antibiotic)

Spectrum of activity: Gram-positive
Details of activity: Elongation Factor Tu inhibitor; active against Gram positives and anaerobes
Description: Stella S, Montanini N, Le Monnier F, et al. Antibiotic GE37468 A: A novel inhibitor of bacterial protein synthesis. Isolation, structure elucidation and bioloigcal properties. 34th-Intersci-Conf-Antimicrobial-Agents-Chemother 1994; 223.
Institute where first reported: Biosearch Italia (Pfizer, USA)
Year first mentioned: 1994
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 1309.46
Iso. SMILES: CC1CC(N2C1C3=NC(=CS3)C4=NC(=CS4)C5=C(C=CC(=N5)C6=NC(=CS6)C(=O)NC(=C)C(=O)NC(=C)C(=O)O)C7=NC(=C(O7)C)C(=O)NC(C8=NC(=CS8)C(=O)NC(C9=NC(CS9)C(=O)NC(C2=O)CC%10=CC=C(C=C%10)O)CC%11=CC=CC=C%11)CC(=O)N)O
InChI Key: AABZZWPMCAZHFC-UHFFFAOYSA-N
Can. SMILES: CC1CC(N2C1C3=NC(=CS3)C4=NC(=CS4)C5=NC(=CC=C5C6=NC(=C(C)O6)C(=O)NC(CC(=O)N)C7=NC(=CS7)C(=O)NC(CC8=CC=CC=C8)C9=NC(CS9)C(=O)NC(CC%10=CC=C(C=C%10)O)C2=O)C%11=NC(=CS%11)C(=O)NC(=C)C(=O)NC(=C)C(=O)O)O
InChI: InChI=1S/C59H52N14O12S5/c1-25-16-43(76)73-46(25)57-71-41(24-90-57)56-67-37(20-86-56)45-32(14-15-33(63-45)53-68-38(21-87-53)48(78)61-26(2)47(77)62-27(3)59(83)84)52-72-44(28(4)85-52)51(81)65-35(19-42(60)75)55-70-39(22-89-55)49(79)64-34(17-29-8-6-5-7-9-29)54-69-40(23-88-54)50(80)66-36(58(73)82)18-30-10-12-31(74)13-11-30/h5-15,20-22,24-25,34-36,40,43,46,74,76H,2-3,16-19,23H2,1,4H3,(H2,60,75)(H,61,78)(H,62,77)(H,64,79)(H,65,81)(H,66,80)(H,83,84)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/16137301
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/49/9/49_9_880/_article

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