Neopyrrolomycin

Class: Phenylpyrrole

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	The base compound was synthesised from 3, 5-dichloroanisole which was then chemically manipulated to generate a number of analogs. Many demonstrated toxicity. The less chlorinated analogue had broad spectrum activity and reduced toxicity.
Institute where first reported:	Wasada University, Japan
Year first mentioned:	1994
Highest developmental phase:	Preclinical
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	C1=CN(C2=C(C(=C(C=C2O)Cl)Cl)Cl)C(=C1Cl)Cl
Isomeric SMILES:	C1=CN(C(=C1Cl)Cl)C2=C(C(=C(C=C2O)Cl)Cl)Cl
InChI:	InChI=1S/C10H4Cl5NO/c11-4-1-2-16(10(4)15)9-6(17)3-5(12)7(13)8(9)14/h1-3,17H
InChI Key:	VQUHAXJBUPCVDX-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/125512

External links:
Guide to Pharmacology:	neopyrrolomycin
Citations:	http://pubs.acs.org/doi/abs/10.1021/np800632f https://www.jstage.jst.go.jp/article/antibiotics1968/43/9/43_9_1192/_article