Compound ID | 708

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Neopyrrolomycin

Class: Phenylpyrrole

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: The base compound was synthesised from 3, 5-dichloroanisole which was then chemically manipulated to generate a number of analogs. Many demonstrated toxicity. The less chlorinated analogue had broad spectrum activity and reduced toxicity.
Institute where first reported: Wasada University, Japan
Year first mentioned: 1994
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 331.41
Iso. SMILES: C1=CN(C(=C1Cl)Cl)C2=C(C(=C(C=C2O)Cl)Cl)Cl
InChI Key: VQUHAXJBUPCVDX-UHFFFAOYSA-N
Can. SMILES: C1=CN(C2=C(C(=C(C=C2O)Cl)Cl)Cl)C(=C1Cl)Cl
InChI: InChI=1S/C10H4Cl5NO/c11-4-1-2-16(10(4)15)9-6(17)3-5(12)7(13)8(9)14/h1-3,17H
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/125512
Guide to Pharmacology: neopyrrolomycin
Citations:
  • http://pubs.acs.org/doi/abs/10.1021/np800632f
  • https://www.jstage.jst.go.jp/article/antibiotics1968/43/9/43_9_1192/_article

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