Compound ID | 71

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PRF-119

Class: Bacteriophage and/or bacteriophage-derived product

Agent Type: Natural product; Bacteriophage or bacteriphage-derived product; Antibiofilm;
Spectrum of activity: Gram-positive
Mechanism of action: Unknown
Target Pathogen: Active against methicillin-sensitive and -resistant Staphylococcus aureus
Propensity to select resistant mutants: Yes
Description: Chimeric phage endolysin; a progenitor of HY-133
Institute where first reported: Institute of Medical Microbiology - University Hospital Münster, Münster,Germany
Year first mentioned: 2011
Highest development stage: Preclinical
Development status: Experimental
External links:
Citations:
  • In Vitro Activity against Staphylococcus aureus of a Novel Antimicrobial Agent, PRF-119, a Recombinant Chimeric Bacteriophage Endolysin By: Idelevich, Evgeny A.; von Eiff, Christof; Friedrich, Alexander W.; et al.
  • https://journals.asm.org/doi/10.1128/aac.00217-11

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