Compound ID | 729

Update compound information

Tolevamer

Synonym(s): GT160-246

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting; Antivirulence;
Spectrum of activity: Gram-positive
Mechanism of action: Binds to Clostridium difficile toxins A and toxin B; toxin neutralization
Target Pathogen: Active against Clostridium difficile
Description: Sodium salt of styrene sulfonate polymer
Institute where first reported: Genzyme Corporation
Year first mentioned: 2000
Highest development stage: Phase 3
Development status: Inactive
Reason dropped: Did not show non-inferiority to vancomycin
Chemical structure(s):
Click here for structure editor
Molecular weight: 228.31
Iso. SMILES: CCC(CC)C1=CC=C(C=C1)S(=O)(=O)O
InChI Key: LZNNAMNPSXBDOT-UHFFFAOYSA-N
Can. SMILES: CCC(CC)C1=CC=C(C=C1)S(=O)(=O)O
InChI: InChI=1S/C11H16O3S/c1-3-9(4-2)10-5-7-11(8-6-10)15(12,13)14/h5-9H,3-4H2,1-2H3,(H,12,13,14)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/58817179
Citations:
  • https://doi.org/10.1529/biophysj.104.041277
  • https://doi.org/10.1086/506349

    • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.