Trospectomycin (U 63366 F)

Class: Aminoglycoside

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Use against CAP and gastrointestinal infections. Spectinomycin analog with greater potency than its parent molecule
Description:	Novak, E., et al. "Safety and preliminary pharmacokinetics of intravenously administered trospectomycin sulfate (U-63,366 F) in man: a novel spectinomycin analogue [abstr 271]." 27th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). 1987.
Institute where first reported:	Pharmacia&Upjohn (Pfizer, US)
Year first mentioned:	1984
Highest developmental phase:	Phase 3
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	CCCC[C@@H]1CC(=O)[C@]2([C@@H](O1)O[C@@H]3[C@H]([C@@H]([C@@H]([C@@H]([C@H]3O2)NC)O)NC)O)O
Isomeric SMILES:	CCCC[C@@H]1CC(=O)[C@]2([C@@H](O1)O[C@@H]3[C@H]([C@@H]([C@@H]([C@@H]([C@H]3O2)NC)O)NC)O)O
InChI:	InChI=1S/C17H30N2O7/c1-4-5-6-8-7-9(20)17(23)16(24-8)25-15-13(22)10(18-2)12(21)11(19-3)14(15)26-17/h8,10-16,18-19,21-23H,4-7H2,1-3H3/t8-,10-,11+,12+,13+,14-,15-,16+,17+/m1/s1
InChI Key:	KHAUBYTYGDOYRU-IRXASZMISA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/55886

External links:
Guide to Pharmacology:	trospectomycin
Citation:	http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1098-0997(1997)5:4%3C280::AID-IDOG4%3E3.0.CO;2-0/abstract