Compound ID | 738

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PNU 288034

Synonym(s): PNU-288034  |  PNU288034

Class: Oxazolidinone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against pathogens causing endocarditis infections
Institute where first reported: Pharmacia Corporation (Pfizer)
Year first mentioned: 2002
Highest development stage: Phase 1
Development status: Inactive
Reason dropped: Insufficient exposure observed
Chemical structure(s):
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Molecular weight: 403.4
Iso. SMILES: CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C(=C2)F)N3CCS(=O)(=O)CC3)F
InChI Key: HSGZLFWXBIVLBD-LBPRGKRZSA-N
Can. SMILES: CC(=O)NC[C@H]1CN(C2=CC(=C(C(=C2)F)N3CCS(=O)(=O)CC3)F)C(=O)O1
InChI: InChI=1S/C16H19F2N3O5S/c1-10(22)19-8-12-9-21(16(23)26-12)11-6-13(17)15(14(18)7-11)20-2-4-27(24,25)5-3-20/h6-7,12H,2-5,8-9H2,1H3,(H,19,22)/t12-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9931003
Guide to Pharmacology: PNU-288034
Citations:
  • http://jpet.aspetjournals.org/content/334/3/936.long
  • https://pubs.acs.org/doi/10.1021/op050207i

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