Compound ID | 745

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FMA-1485

Class: Macrolide (14-membered macrolide, ketolide)

Spectrum of activity: Gram-positive
Details of activity: Binds to the peptidyl transferase component of the 50S subunit of ribosomes, thus inhibiting peptide bond formation and bacterial protein synthesis. Mainly active against Gram-positive bacteria.
Institute where first reported: Taisho Pharmaceuticals
Year first mentioned: 1999
Highest developmental phase: Preclinical
Development status: Discontinued
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/substance/275243634
Citations:
  • Sugiyama H . et al: FMA1485, a Novel 2-Fluoroketolide: In Vitro and In Vivo Antibacterial Activities Against Respiratory Tract Pathogens. ICAAC 2006, F1-1985
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