Compound ID | 750

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A-217213

Class: Macrolide

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against pathogen causing pneumococcal infections
Description: An 11,12-carbamate ketolide
Institute where first reported: Abbott Laboratories (Abbvie, USA)
Year first mentioned: 2001
Development status: Experimental
Chemical structure(s):
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Molecular weight: 777.94
Iso. SMILES: C[C@H]1C([C@H](C)[C@H]2NC(O[C@]2(C)[C@@H](CC)OC([C@H](C)C([C@@H](C([C@](C1)(OCCC#CC3=CN=C4C(C=CC=C4)=C3)C)O[C@@H]5O[C@H](C)C[C@H](N(C)C)[C@H]5O)C)=O)=O)=O)=O
InChI Key: XABGDHGZSNDKTO-MCINJTITSA-N
Can. SMILES: CC[C@@H]1[C@]2(C)[C@@H]([C@@H](C)C(=O)[C@H](C)C[C@@](C)(C([C@@H](C)C(=O)[C@@H](C)C(=O)O1)O[C@H]3[C@@H]([C@H](C[C@@H](C)O3)N(C)C)O)OCCC#CC4=CC5=C(C=CC=C5)N=C4)NC(=O)O2
InChI: InChI=1S/C43H59N3O10/c1-11-33-43(8)37(45-41(51)56-43)26(4)34(47)24(2)22-42(7,52-19-15-14-16-29-21-30-17-12-13-18-31(30)44-23-29)38(27(5)35(48)28(6)39(50)54-33)55-40-36(49)32(46(9)10)20-25(3)53-40/h12-13,17-18,21,23-28,32-33,36-38,40,49H,11,15,19-20,22H2,1-10H3,(H,45,51)/t24-,25-,26+,27+,28-,32+,33-,36-,37-,38?,40+,42+,43-/m1/s1
External links:
Citation: https://doi.org/10.1128/9781555815929.ch19

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