Compound ID | 752

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GI-448

Class: Macrolide

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Antimycobacterial
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against clarithromycin-resistant Mycobacterium avium and Mycobacterium tuberculosis
Description: A 9-oxime ether derivative of erythromycin
Institute where first reported: Hokuriku Seiyaku (Abbvie, USA)
Year first mentioned: 2001
Development status: Experimental
Chemical structure(s):
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Molecular weight: 915.2
Iso. SMILES: CC[C@@H]1[C@@]([C@@H]([C@H](/C(=N/OCCCC2CCCCC2)/[C@@H](CC([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)OC(=O)C)(C)OC)C)O[C@H]4[C@@H]([C@H](C[C@H](O4)C)N(C)C)O)(C)O)C)C)O)(C)O
InChI Key: SYKZQWUZDVANMW-FXMMUECYSA-N
Can. SMILES: CC[C@@H]1[C@](C)([C@@H]([C@@H](C)/C(=N/OCCCC2CCCCC2)/[C@H](C)CC(C)([C@@H]([C@@H](C)[C@@H]([C@@H](C)C(=O)O1)O[C@H]3C[C@](C)([C@H]([C@H](C)O3)OC(=O)C)OC)O[C@H]4[C@@H]([C@H](C[C@@H](C)O4)N(C)C)O)O)O)O
InChI: InChI=1S/C48H86N2O14/c1-15-36-48(11,56)41(53)29(4)38(49-58-23-19-22-34-20-17-16-18-21-34)27(2)25-46(9,55)42(64-45-39(52)35(50(12)13)24-28(3)59-45)30(5)40(31(6)44(54)62-36)63-37-26-47(10,57-14)43(32(7)60-37)61-33(8)51/h27-32,34-37,39-43,45,52-53,55-56H,15-26H2,1-14H3/b49-38+/t27-,28-,29+,30+,31-,32+,35+,36-,37+,39-,40+,41-,42-,43+,45+,46?,47-,48-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9575657
Citation: https://doi.org/10.1016/s1472-9792(08)70036-2

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