Compound ID | 753

Update compound information

HMR 3004

Synonym(s): RU 64004

Class: Macrolide (ketolide)

Spectrum of activity: Gram-positive
Details of activity: Antistreptococcal activity; when tested against Campylobacter spp., RU 664004 was not as active as faropenem, erythromycin, clarithromycin, azithromycin or ofloxacin. When its activity against S. pneumoniae, E. faecalis and E. faecium, RU 664004 was better than erythromycin
Description: Schulin T, Wennersten CB, Eliopoulos GM, et al. In vitro activity of RU 64004, a new ketolide antibiotic against Gram-positive bacteria. 36th-Intersci-Conf-Antimicrobial-Agents-Chemother 1996; 138.
Institute where first reported: Hoechst Marion Roussel (Sanofi-Aventis, France); Aventis (Sanofi Aventis, France)
Year first mentioned: 1996
Highest developmental phase: Phase 2
Development status: Inactive
Chemical structure(s):
Click here for structure editor
Molecular weight: 796.99
Iso. SMILES: CCC1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)NCCCC4=CC=NC5=CC=CC=C45)C
InChI Key: NEXGHZNDZNYBRI-IGXXTDCFSA-N
Can. SMILES: CCC1[C@]2(C)[C@@H]([C@@H](C)C(=O)[C@H](C)C[C@](C)([C@@H]([C@@H](C)C(=O)[C@@H](C)C(=O)O1)O[C@H]3[C@@H]([C@H](C[C@@H](C)O3)N(C)C)O)OC)N(C(=O)O2)NCCCC4=CC=NC5=C4C=CC=C5
InChI: InChI=1S/C43H64N4O10/c1-12-33-43(8)37(47(41(52)57-43)45-20-15-16-29-19-21-44-31-18-14-13-17-30(29)31)26(4)34(48)24(2)23-42(7,53-11)38(27(5)35(49)28(6)39(51)55-33)56-40-36(50)32(46(9)10)22-25(3)54-40/h13-14,17-19,21,24-28,32-33,36-38,40,45,50H,12,15-16,20,22-23H2,1-11H3/t24-,25-,26+,27+,28-,32+,33?,36-,37-,38-,40+,42-,43-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/165359544
Citation: https://journals.asm.org/doi/10.1128/aac.41.10.2149?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.