Compound ID | 753

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HMR 3004

Synonym(s): RU 64004

Class: Macrolide

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against pathogens causing respiratory infections such as Streptococcus, Moraxella, and Haemophilus sp.
Description: A hydrazono ketolide; Schulin T, Wennersten CB, Eliopoulos GM, et al. In vitro activity of RU 64004, a new ketolide antibiotic against Gram-positive bacteria. 36th-Intersci-Conf-Antimicrobial-Agents-Chemother 1996; 138.
Institute where first reported: Hoechst Marion Roussel (Sanofi-Aventis, France); Aventis (Sanofi Aventis, France)
Year first mentioned: 1996
Highest development stage: Phase 2
Development status: Inactive
Chemical structure(s):
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Molecular weight: 796.99
Iso. SMILES: CCC1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)NCCCC4=CC=NC5=CC=CC=C45)C
InChI Key: NEXGHZNDZNYBRI-IGXXTDCFSA-N
Can. SMILES: CCC1[C@]2(C)[C@@H]([C@@H](C)C(=O)[C@H](C)C[C@](C)([C@@H]([C@@H](C)C(=O)[C@@H](C)C(=O)O1)O[C@H]3[C@@H]([C@H](C[C@@H](C)O3)N(C)C)O)OC)N(C(=O)O2)NCCCC4=CC=NC5=C4C=CC=C5
InChI: InChI=1S/C43H64N4O10/c1-12-33-43(8)37(47(41(52)57-43)45-20-15-16-29-19-21-44-31-18-14-13-17-30(29)31)26(4)34(48)24(2)23-42(7,53-11)38(27(5)35(49)28(6)39(51)55-33)56-40-36(50)32(46(9)10)22-25(3)54-40/h13-14,17-19,21,24-28,32-33,36-38,40,45,50H,12,15-16,20,22-23H2,1-11H3/t24-,25-,26+,27+,28-,32+,33?,36-,37-,38-,40+,42-,43-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/165359544
Citations:
  • https://doi.org/10.1128/aac.42.6.1392
  • https://doi.org/10.1128/aac.41.10.2149

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