Compound ID | 754

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HMR 3787

Class: Macrolide

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Effective against Gram positive cocci and H. influenzae
Description: A 2-fluoroketolide derivative
Institute where first reported: Hoechst Marion Roussel (Sanofi-Aventis, France)
Year first mentioned: 1999
Development status: Experimental
Chemical structure(s):
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Molecular weight: 803.96
Iso. SMILES: CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@](C(=O)O1)(C)F)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCN4C=NC5=C4N=CC=C5)C
InChI Key: NRYQCCZBHGMXIN-SAWHFZNOSA-N
Can. SMILES: CC[C@@H]1[C@]2(C)[C@@H]([C@@H](C)C(=O)[C@H](C)C[C@](C)([C@@H]([C@@H](C)C(=O)[C@@](C)(C(=O)O1)F)O[C@H]3[C@@H]([C@H](C[C@@H](C)O3)N(C)C)O)OC)N(CCCCN4C=NC5=C4N=CC=C5)C(=O)O2
InChI: InChI=1S/C41H62FN5O10/c1-12-29-41(8)32(47(38(52)57-41)19-14-13-18-46-22-44-27-16-15-17-43-35(27)46)25(4)30(48)23(2)21-39(6,53-11)34(26(5)33(50)40(7,42)37(51)55-29)56-36-31(49)28(45(9)10)20-24(3)54-36/h15-17,22-26,28-29,31-32,34,36,49H,12-14,18-21H2,1-11H3/t23-,24-,25+,26+,28+,29-,31-,32-,34-,36+,39-,40+,41-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6918384
Citations:
  • https://doi.org/10.1128/AAC.47.1.405-407.2003
  • https://doi.org/10.1128/aac.45.11.3242-3245.2001

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