Compound ID | 755

Update compound information

CGP7040

Synonym(s): C70

Class: Rifamycin

Spectrum of activity: Gram-negative
Details of activity: Protein 50S ribosomal subunit inhibitor
Institute where first reported: Novartis, Switzerland
Year first mentioned: 1987
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Not as active as rifabutin and rifapentine
Chemical structure(s):
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Molecular weight: 914.09
Iso. SMILES: C[C@H]1/C=C/C=C(\C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)O[C@@](C4=O)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C(=C2N5CCN(CC5)CC6=C(C=C(C=C6C)C)C)O)O)/C
InChI Key: ILHGDLYAJLWSGO-FIVPFQPSSA-N
Can. SMILES: CC1=CC(=C(CN2CCN(CC2)C3=C(C4=C5C6=C(C)C(=C4C(=C3NC(=O)/C(=C\C=C\[C@H](C)[C@@H]([C@@H](C)[C@H]([C@@H](C)[C@@H]([C@H](C)[C@H](/C=C/O[C@](C)(C5=O)O6)OC)OC(=O)C)O)O)/C)O)O)O)C(=C1)C)C
InChI: InChI=1S/C51H67N3O12/c1-25-22-28(4)35(29(5)23-25)24-53-17-19-54(20-18-53)41-40-45(59)38-37(46(41)60)39-48(33(9)44(38)58)66-51(11,49(39)61)64-21-16-36(63-12)30(6)47(65-34(10)55)32(8)43(57)31(7)42(56)26(2)14-13-15-27(3)50(62)52-40/h13-16,21-23,26,30-32,36,42-43,47,56-60H,17-20,24H2,1-12H3,(H,52,62)/b14-13+,21-16+,27-15-/t26-,30+,31+,32+,36-,42-,43+,47+,51-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6473879
Citations:
  • http://aac.asm.org/content/35/10/2026.long
  • https://www.sciencedirect.com/science/article/pii/0041387987900547?via%3Dihub

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