Eperezolid

Synonym(s): PNU 100592  |  U 100592  |  U100592

Class: Oxazolidinone

Spectrum of activity:	Gram-negative
Details of activity:	Protein 50S ribosomal subunit inhibitor
Description:	Pawsey SD, Harry JD, Stalker DJ. 1st administration of a new oxazolidinone antibiotic (U-100592) to man. 35th-ICAAC 1995;15
Institute where first reported:	Pharmacia & Upjohn (Pfizer, USA)
Year first mentioned:	1995
Highest developmental phase:	Phase 3
Development status:	Inactive
Reason Dropped:	Linezolid displayed better activities than eperezolid including development of resistance (1)

Chemical structure(s):
Canonical SMILES:	CC(=O)NC[C@H]1CN(C2=CC=C(C(=C2)F)N3CCN(CC3)C(=O)CO)C(=O)O1
Isomeric SMILES:	CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCN(CC3)C(=O)CO)F
InChI:	InChI=1S/C18H23FN4O5/c1-12(25)20-9-14-10-23(18(27)28-14)13-2-3-16(15(19)8-13)21-4-6-22(7-5-21)17(26)11-24/h2-3,8,14,24H,4-7,9-11H2,1H3,(H,20,25)/t14-/m0/s1
InChI Key:	SIMWTRCFFSTNMG-AWEZNQCLSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/73214

External links:
Guide to Pharmacology:	eperezolid
Citation:	https://www.ncbi.nlm.nih.gov/pubmed/11747939