Compound ID | 758

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PNU-173995

Class: Oxazolidinone

Description: Friis JM, Steenwyk RC, Williams MG, Palandra J, Hosley JD, et al. Interspecies comparison of the pharmacokinetics and metabolism of an oxazolidinone thioamide antibacterial (PNU-173995). 41st-ICAAC 2001;226.
Institute where first reported: Pharmacia Corp. (Pfizer, USA)
Year first mentioned: 2001
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Poor bioavailability in dogs and monkeys. In monkeys and rats, there was also poor clearance
Chemical structure(s):
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Molecular weight: 410.46
Iso. SMILES: CC(=S)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCN(CC3)C(=O)CO)F
InChI Key: SYUFGFAMGWERAW-AWEZNQCLSA-N
Can. SMILES: CC(=S)NC[C@H]1CN(C2=CC=C(C(=C2)F)N3CCN(CC3)C(=O)CO)C(=O)O1
InChI: InChI=1S/C18H23FN4O4S/c1-12(28)20-9-14-10-23(18(26)27-14)13-2-3-16(15(19)8-13)21-4-6-22(7-5-21)17(25)11-24/h2-3,8,14,24H,4-7,9-11H2,1H3,(H,20,28)/t14-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9822824
Citation:

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