Compound ID | 760

Update compound information

Vertilmicin

Class: Aminoglycoside

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Protein synthesis inhibitor
Description: Semisynthetic derivative of the natural product verdamicin; Yuan M, Yang XY, Li CR, et al. Susceptibility of Vertilmicin to Modifications by Aminoglycoside Modifying Enzymes. 50th-ICAAC 2010
Institute where first reported: Inst. of Med.l Biotechnology, China
Year first mentioned: 2010
Highest development stage: Preclinical
Development status: Experimental
Chemical structure(s):
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Molecular weight: 489.61
Iso. SMILES: CCN[C@@H]1C[C@@H]([C@H]([C@@H]([C@H]1O[C@@H]2[C@@H]([C@H]([C@@](CO2)(C)O)NC)O)O)O[C@@H]3[C@@H](CC=C(O3)C(C)N)N)N
InChI Key: QVRLHIRFLRXFIW-OFMFRWEUSA-N
Can. SMILES: CCN[C@@H]1C[C@@H]([C@H]([C@@H]([C@H]1O[C@@H]2[C@@H]([C@H]([C@](C)(CO2)O)NC)O)O)O[C@@H]3[C@@H](CC=C(C(C)N)O3)N)N
InChI: InChI=1S/C22H43N5O7/c1-5-27-13-8-12(25)17(33-20-11(24)6-7-14(32-20)10(2)23)15(28)18(13)34-21-16(29)19(26-4)22(3,30)9-31-21/h7,10-13,15-21,26-30H,5-6,8-9,23-25H2,1-4H3/t10?,11-,12+,13-,15+,16-,17-,18+,19-,20-,21-,22+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/101268397
Guide to Pharmacology: vertilmicin
Citation: https://doi.org/10.1128/aac.00223-09

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