Compound ID | 764

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Boxazomycin B

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Antimycobacterial
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Streptococcus pyogenes, Staphylococcus aureus, and Mycobacterium smegmatis
Description: Natural product from Actinomycete strain; Song Y, Domagala JM, Turner WR, et al. Boxazomycin analogues as new antibacterial agents synthesis and structure-activity relationships. 35th-Intersci-Conf-Antimicrobial-Agents-Chemother 1995; 116.
Institute where first reported: Parke Davis Pharmaceutical Research (Pfizer, USA)
Year first mentioned: 1995
Development status: Experimental
Chemical structure(s):
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Molecular weight: 300.27
Iso. SMILES: CC1=CC(=C(C2=C1OC(=N2)C3=NC(=NC=C3O)C)C(=O)N)O
InChI Key: ILGGOCYCDJJADI-UHFFFAOYSA-N
Can. SMILES: CC1=C2C(=C(C(=C1)O)C(=O)N)N=C(C3=NC(=NC=C3O)C)O2
InChI: InChI=1S/C14H12N4O4/c1-5-3-7(19)9(13(15)21)11-12(5)22-14(18-11)10-8(20)4-16-6(2)17-10/h3-4,19-20H,1-2H3,(H2,15,21)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/135527050
Citation: https://doi.org/10.1021/ja00217a043

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